a lab mouse crawls around a terrarium

Volume 74  Issue 3

Fall 2025

In this Issue

A look at the future of “organ chips” and other emerging laboratory research and testing technologies that avoid the use of animals while often producing more human-relevant results.

Russell and Burch’s landmark 1959 book, The Principles of Humane Experimental Technique, introduced the 3Rs of more humane animal research: replacement of animals as models, reduction in the number of animals used, and refinement of housing and handling methods to reduce animal stress and suffering. The authors considered “absolute replacement” to be the “absolute ideal.” Technological advances in “new approach methodologies” (NAMs), including nonliving organoids and organ chips, are increasingly making replacement feasible in some arenas. Yet absolute replacement still faces significant hurdles—technological, cultural, and otherwise.

Photo by Bradengar S/500px

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Featured in This Issue

Assessing Population Vulnerability of American Pika via a Multifaceted, Noninvasive Molecular Genetic Approach

Endangered Species, Terrestrial Wildlife

AWI’s Nancy Blaney: Tenacious in Making Government Work for Animals

All Programs
truckers mount and spray animal trailers at a gas station

Federal Protection of Animals in Transport Goes off the Rails

Farmed Animals
gray whale sprays out from its blowhole in ocean water

Gray Whale Hunt Edges Toward Approval Amid Staggering Population Decline

Endangered Species, Marine Wildlife
Hi-Tech Acoustic Curtain Protects Wildlife from Highway Collisions
Endangered Species, Terrestrial Wildlife
Replacing Animals in Experimentation: Where We Are, Where We’re Going
Animals in Laboratories
Simple Snares Exert Stranglehold on Wild Animal Populations
Terrestrial Wildlife
The Hidden Web: International Trade in Insects and Arachnids as Pets
Terrestrial Wildlife

More in this Issue

AWI Joins Partnership to Advance Nonanimal Experimentation Methods

 Animals in Laboratories

AWI Launches Revamped Refinement Database

 Animals in Laboratories

AWI’s Christine Stevens Wildlife Award Recipients for 2025

 Marine Wildlife, Terrestrial Wildlife

Administration Takes Aim at California Animal Welfare Law

 Farmed Animals

Alan Cumming Urges End to Pet Primate Trade

 Terrestrial Wildlife

Apply Now: Funding Available to Develop or Implement Refinements

 Animals in Laboratories

Beagle Breeder Under Investigation

 Animals in Laboratories

Court Corrals BLM’s Wild Horse Removal Plan

 Equines, Terrestrial Wildlife

Egg Producer Loses 6 Million Hens to Bird Flu

 Farmed Animals

Fending Off Octopus and Marine Fish Factory Farms

 Farmed Animals, Marine Wildlife

Gaining Ground Against Commercial Kangaroo Slaughter

 Terrestrial Wildlife

House Committee Leadership Bullish on Anti-wildlife Bills

 Endangered Species, Marine Wildlife, Terrestrial Wildlife

Kenya Wildlife Service Keeps Eyes in the Sky with Assist from AWI

 Terrestrial Wildlife

Lax Label Claim Oversight Undermines Consumer Expectations

 Farmed Animals

Life After the Lab

 Animals in Laboratories, Companion Animals

NIH Announces Major Change in Funding Priorities

 Animals in Laboratories

Protecting Wild Species from Cruel Capture and Killing Methods

 Terrestrial Wildlife

Securing Funding for Animal Welfare Priorities

 Companion Animals, Equines, Farmed Animals

Sustaining the Seas: Outcomes of Third UN Ocean Conference

 Endangered Species, Marine Wildlife

Thirst for Oil Threatens Marine Ecosystems

 Marine Wildlife

Reviews

whale swimming with calf near surface

Ocean With David Attenborough

 Marine Wildlife
Out of SIght Book Cover

Out of Sight

 Farmed Animals
colorful assortment of illustrated outlines of different dog breeds

This Dog Will Change Your Life

 Companion Animals